A Single Dose of Kudzu Extract Reduces Alcohol Consumption in a Binge Drinking Paradigm PMC

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No side effects have been reported in clinical studies when kudzu is taken by mouth. There is, however, one case report of allergic reaction following use of a combination herbal product containing kudzu . Another report suggests that taking kudzu root by mouth might cause liver damage. “Alcohol-induced increases in dopamine in the nucleus accumbens are prevented by CVT in a dose-dependent manner,” said Diamond. Compared to weeks in which the participants took no pill or a placebo, individuals with kudzu in their system consumed almost half as much alcohol—and showed no side effects or awareness of the drug. A recent study by Harvard-affiliated researchers revealed that kudzu—an herb found to reduce alcohol consumption—does not work by increasing the intoxicating effects of alcohol so that individuals get drunk faster. Another study found that people who took puerarin, an isoflavone extract from the kudzu plant, prior to drinking took longer to consume alcoholic beverages . While the blood flow theory of kudzu for alcoholism may be true, there is likely more going on here. Kudzu contains several active isoflavones, which are natural plant chemicals with antioxidant effects. This compound has a positive effect on the central nervous system and the brain.

The real danger may be the possible delay in seeking professional help for the dependence. If asked about herbal treatments for a drinking problem, it is advisable to recommend speaking with a professional rather than self-treatment with over-the-counter supplements. Between drinks, the subjects rested their beer on a scale so researchers could monitor exactly how much they were drinking. They then either took 500 mg kudzu plant capsules three times a day or a placebo for a week and then returned to the lab. After observation, there kudzu alcohol addiction was a “washout” period and treatments were then reversed – those who had been taking kudzu plant were given a placebo and vice versa. Behavior-observing researchers did not know who had been given what. The subjects who had been taking kudzu plant showed almost a 50 percent average decrease in beer intake and took smaller sips, while placebo takers drank the same quantity as before. No side effects were reported or observed from kudzu plant intake. One of the ancillary factors in alcohol dependence is blood sugar imbalances.

Herbal Approaches to Alcohol Dependence: Evidence and Risks

Puerarin is also less potent than other parts of the kudzu plant, so it has few side effects and has none of the estrogenic activity found in other components, making it safe for women. An extract of the Chinese herb kudzu dramatically reduces drinking and may be useful in the treatment of alcoholism and curbing binge drinking, according to a new study by McLean Hospital and Harvard Medical School researchers. In retrospect, my experience demonstrates the utility of kudzu for alcoholism. If kudzu alcohol addiction I had been committed to using kudzu to wean off of alcohol and then quit, it might have been a very valuable part of my recovery. I did not know at the time that people also use kudzu to treat alcohol withdrawal symptoms; nor did I care, because I did not intend to quit at the time. A study of heavy drinkers who were not in a treatment program found that taking kudzu had no effect on their alcohol cravings. But it did reduce the number of drinks they had each week by a third to a half.

We are proposing that a novel approach to nutritional supplementation may be required to target the RDS role in alcoholism and glucose homeostasis . Certainly an added stress of attempting to eliminate alcohol usage is the drastic swings in blood sugar, which when occurring may stimulate a stronger desire to drink . Any natural means to balance blood sugar can therefore be of great cessation benefit to alcohol programs. The researchers looked at the isoflavone puerarin, which is extracted from kudzu root. The herb called the kudzu is a high climbing, coarse textured twining and trailing type of perennial vine found in parts of Asia and naturalized elsewhere . Chinese traditional medicine makes use of the huge root that grows to the size of an adult Sober House human body-the kudzu called gégen in China, is a major source for many modern herbal products as well as traditional Chinese medications. In China, the kudzu or gégen is found growing in shaded areas along mountains, in the fields and along roadsides, in thickets and thin forests all over the country. Herbal products are also made from the root of another related Asian species of kudzu, called Pueraria thomsonii. The main compounds found in the root of the kudzu are the isoflavones, like the compound daidzein, also included are the isoflavone glycosides, like daidzin and the compound called puerarin. In any batch of kudzu roots, the total content of isoflavone often varies widely from 1.77%-12.0% depending on the growing conditions of the herb.

Kudzu Vine Extract for Alcohol Treatment: The Study

At this time there is not enough scientific information to determine an appropriate range of doses for kudzu. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Early research suggests that injecting puerarin, a chemical in kudzu, intravenously along with usual treatment might help some people after a heart attack. Some early research suggests that taking puerarin, a chemical in kudzu, alone or with aspirin, might improve brain function in some people after stroke. However, other research shows that injecting puerarin intravenously does not reduce death or dependency after a stroke. Early research suggests that taking puerarin, a chemical in kudzu, 400 mg/day by mouth for 10 days might improve heart function in people with heart failure. Early research suggests that taking puerarin, a chemical in kudzu, 750 mg daily by mouth along with the diabetes medication rosiglitazone improves kidney function in people with diabetic nephropathy.

Known as TAS2R’s, these receptors are located throughout the gut and are set to detect a variety of differing bitter profiles. Throughout the gut and endocrine system, digestive secretions are promoted in the stomach, pancreas, gall bladder, liver, and small and large intestine. Bitters have been used to help relief symptoms of constipation, flatulence, appetite loss, vomiting, heartburn, abdominal pain and nausea . The mental health of children and young people with some long term physical conditions could benefit from cognitive behavioral therapy , according to a recent study. More than half of young adults at risk for alcohol-related harm report symptoms of insomnia. Cognitive behavioral therapy is one of the first-line treatments for insomnia, but it’s never been … “The most urgent need is helping people who cannot help themselves, who need a drug to help them stop drinking,” Keung said. None of the subjects had any side effects from mixing kudzu with beer.

Kudzu

It is one of the substances known as isoflavones found in kudzu. James Lake, M.D., a clinical assistant professor at the University of Arizona College of Medicine, works to transform mental health care through the evidence-based uses of alternative therapies. In view of these findings, individuals who are attempting to taper and discontinue benzodiazepines following prolonged use for insomnia should be encouraged to take a nightly 2mg dose of controlled-release melatonin. The above findings should be viewed in the context of a 2105 systematic review and meta-analysis that found no evidence that melatonin facilitated benzodiazepine discontinuation and inconsistent effects of melatonin on sleep quality . Mentat™, a proprietary Ayurvedic compound herbal formula, has been found to reverse effects of acute benzodiazepine withdrawal in dependent mice, and may provide similar benefits in humans (Kulkarni 1994; Kulkarni 1992). Early research suggests that taking a combination supplement containing kudzu isoflavones along with other ingredients might improve exercise performance in some people. Some research suggests that injecting puerarin, a chemical in kudzu, intravenously does not improve vision in people with diabetic retinopathy.

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The research team set up an apartment with a TV and DVD player and a refrigerator stocked with favorite beers. “Essentially we know a little bit more about how kudzu doesn’t work at the moment,” said study co-author David M. Penetar, assistant professor of psychology in Harvard Medical School’s Psychiatry Department and a research psychologist at McLean Hospital. Donate now to support mental health care, research, and education. Whether you are early in your career or a seasoned professional, McLean has resources to support you through a lifetime of helping patients succeed. Fortunately, these 11 vitamins and supplements can boost your energy levels when you need it most. The most popular forms available appear to be powdered drink mixes, capsules, disintegrating tablets, and liquid extract drops. Kudzu root may help treat some of the most common menopausal complaints, including hot flashes and night sweats.

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